A Broad-Spectrum Microbicide with Virucidal Activity against Sexually Transmitted Viruses
نویسندگان
چکیده
منابع مشابه
Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1.
Topical microbicides for use by women to prevent the transmission of human immunodeficiency virus (HIV) and other sexually transmitted infections are urgently required. Dendrimers are highly branched nanoparticles being developed as microbicides. SPL7013 is a dendrimer with broad-spectrum activity against HIV type I (HIV-1) and -2 (HIV-2), herpes simplex viruses type-1 (HSV-1) and -2 (HSV-2) an...
متن کاملSexually transmitted viruses.
Human viruses known to be spread by sexual contact include herpes simplex viruses (HSV), papillomaviruses (HPV), human immunodeficiency virus (HIV), hepatitis B virus, and cytomegalovirus. Infections with the first three (HSV, HPV, and HIV) have reached epidemic proportions and pose global health concerns. Most of what we know about these human pathogens has been learned only recently, owing to...
متن کاملVirucidal Activity of Disinfectants Against Parvoviruses and Reference Viruses
The conditions under which microbiologists, emergency responders, and other individuals are working with pathogens vary greatly. Best practices and PPE used to reduce risk to an acceptable level are determined by conducting a thorough risk assessment. The top left photo: Participants from countries supported by President Obama's Emergency Plan for AIDS Relief program (PEPFAR) observe specimen l...
متن کاملVaccines against sexually transmitted diseases
Introduction Human sexually transmitted infections are prevalent throughout the world. Several have been associated with adverse pregnancy outcome and increased susceptibility to HIV infection, in addition to the discomfort of inflammation of the genital tract. Yet vaccines to protect against the infection at the genital mucosa are not available. Hepatitis B is an exception, but this virus beco...
متن کاملBroad-spectrum virucidal activity of (NVC-422) N,N-dichloro-2,2-dimethyltaurine against viral ocular pathogens in vitro.
PURPOSE Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthalmic viral pathogens. METHODS The virucidal activity of NVC-422 against seve...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1999
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.43.2.314